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Blizard Institute - Faculty of Medicine and Dentistry

Professor Paul Pfeffer, MA MBBS MRCP PhD

Paul

Clinical Professor of Respiratory Medicine

Email: p.pfeffer@qmul.ac.uk
Website: https://orcid.org/0000-0003-0369-2885

Profile

Paul Pfeffer is a Clinical Professor of Respiratory Medicine and Consultant Respiratory Physician with Specialist Interest in Asthma at Queen Mary University of London and Barts Health NHS Trust, London, UK. 

He studied medicine at University of Cambridge and University College London.  After qualification he completed medical training placements in the North East London training rotation during which he undertook a PhD at King’s College London as a Wellcome Trust Clinical Research Training Fellowship.  He was appointed as a Consultant Respiratory Physician at Barts Health in 2016 and as a Clinical Professor at QMUL in 2026.

Research interests include the capacity of the environment to subvert homeostatic and protective immune responses in the lung; and severe asthma cohort studies including the UK and International Severe Asthma Registries, of both of which he is on the Steering Committee; and applied respiratory research.   His clinical interest is in how personalisation of treatment to each patient, both in terms of individual disease immunology and healthcare beliefs, can improve patient quality of life, reduce breathlessness and reduce exacerbations.

 

Teaching

QMUL medical students

  •  Paul actively engages in teaching activities at QMUL, teaching MB BS Y2 and GEP Y1 students on asthma and applied lung physiology.

 

Academic fellows and PhD students

  •  He supervises clinical academic fellows, and clinical & non-clinical PhD students.

Research

Research Interests:

Paul has an active programme of respiratory research at Queen Mary University of London. Research interests include the capacity of environmental factors such as air pollution and airways infections to subvert homeostatic and protective adaptive immune responses in the lung resulting in airway pathology; severe asthma cohort studies including the UK and International Severe Asthma Registries, of both of which he is on the Steering Committee; and applied respiratory research.  Paul is Principal Investigator for clinical trials in asthma and COPD at Barts/QMUL.

Publications

  • Skene IP, Astin-Chamberlain R, Pike KC, Griffiths C, Steed L, Pfeffer PE. Optimising long-term management in acute asthma presentations to the emergency department: an interview study on patient beliefs. BMJ Open Respir Res. 2025 Jul 7;12(1):e002962.

 

  • Jackson DJ, Wechsler ME, Jackson DJ, Bernstein D, Korn S, Pfeffer PE, Chen R, Saito J, de Luíz Martinez G, Dymek L, Jacques L, Bird N, Schalkwijk S, Smith D, Howarth P, Pavord ID; SWIFT-1 and SWIFT-2 Investigators. Twice-Yearly Depemokimab in Severe Asthma with an Eosinophilic Phenotype. N Engl J Med. 2024 Sep 9. doi: 10.1056/NEJMoa2406673.

 

  • Pfeffer PE, Brown T, Chaudhuri R, Faruqi S, Gore R, Heaney LG, Mansur AH, Pantin T, Patel M, Rupani H, Siddiqui S, Vyas A, Busby J; UK Severe Asthma Registry. Impact of comorbidities on EQ-5D quality-of-life index in severe asthma. J Allergy Clin Immunol Glob. 2024 May 31;3(3):100286. doi: 10.1016/j.jacig.2024.100286. eCollection 2024 Aug.

 

  • Esposito I, Kontra I, Giacomassi C, Manou-Stathopoulou S, Brown J, Stratton R, Verykokou G, Buccafusca R, Stevens M, Nissim A, Lewis MJ, Pfeffer PE. Identification of autoantigens and their potential post-translational modification in EGPA and severe eosinophilic asthma. Front Immunol. 2023 Jun 2;14:1164941.

 

  • Pfeffer PE, Mudway IS, Grigg J. Air Pollution and Asthma: Mechanisms of Harm and Considerations for Clinical Interventions. Chest. 2021 Apr;159(4):1346-1355.

 

Supervision

 

  • Sonay Beyatli, PhD Student: The role of autoantibodies in eosinophilic asthma (joint-supervisor 2025-)
  • Ivy Akehurst, PhD Student: The impact of inflammation on protective immunity to respiratory pathogens (second supervisor 2024-)
  • Rebekah Young, PhD Student: Patient barriers and facilitators to use of a digital health application in lung cancer prehabilitation: a qualitative study (joint-supervisor 2023-)
  • Imogen Skene, PhD Student: Improving long term asthma control in adults attending Emergency Departments with asthma attacks: a mixed-methods study (joint-supervisor, 2020-2024 (completed))

 

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