PHURI Seminar Series
When: Tuesday, October 1, 2024, 12:00 PM - 1:00 PM
Where: Basement, Empire House 67-75 New Road - Hybrid
Speaker: Paul O'Reilly - Icahn School of Medicine at Mount Sinai
While genetic architecture has been investigated extensively at the trait-level, little is known about how genetic architecture varies among individuals across the trait continuum. Here
we reveal striking departures from polygenicity in the distribution tails of a range of human traits (e.g. in individuals with high LDL, low/high sitting height, early age of menopause) and implicate stabilising selection as a chief cause.