Dr Moneeza Siddiqui

Profile

I am a Senior Lecturer in Genetic Epidemiology at Queen Mary University of London, where I lead an independent research programme investigating the biological basis of type 2 diabetes in underrepresented populations. I serve on the Executive Committee of Genes & Health, the world's largest community-based cohort of British Bangladeshi and Pakistani people, and am Scientific Consultant in Genetic Epidemiology at the Madras Diabetes Research Foundation, India. 

My research combines human genetics, epidemiology and multi-omics to uncover disease mechanisms and advance more equitable approaches to precision medicine. I have established international collaborations spanning the UK, India, North America and Southeast Asia, and am Associate Director of the Wellcome-funded Health Data in Practice PhD programme, where I am committed to developing the next generation of interdisciplinary health data scientists.

Research

Research Interests:

Genetic epidemiology of type 2 diabetes in south Asian populations; diverse populations; young and lean onset T2D; precision medicine; multi-omics to study disease aetiology.

Publications

Please click through to see a complete list of Moneeza's publications

Siddiqui, M.K., Anjana, R.M., Dawed, A.Y. et al. Young-onset diabetes in Asian Indians is associated with lower measured and genetically determined beta cell function. Diabetologia 65, 973–983 (2022). https://doi.org/10.1007/s00125-022-05671-z 

Sundararajan Srinivasan, Samuel Liju, Natarajan Sathish, Moneeza K. Siddiqui, Ranjit Mohan Anjana, Ewan R. Pearson, Alexander S.F. Doney, Viswanathan Mohan, Venkatesan Radha, Colin N.A. Palmer; Common and Distinct Genetic Architecture of Age at Diagnosis of Diabetes in South Indian and European Populations. Diabetes Care 1 August 2023; 46 (8): 1515–1523. https://doi.org/10.2337/dc23-0243 

Anjana RM, Baskar V, Nair ATN, et al. Novel subgroups of type 2 diabetes and their association with microvascular outcomes in an Asian Indian population: a data-driven cluster analysis: the INSPIRED study BMJ Open Diabetes Research and Care 2020;8:e001506. doi: 10.1136/bmjdrc-2020-001506 

Margherita Bigossi, Cyrielle Maroteau, Adem Y Dawed, Alasdair Taylor, Sundararajan Srinivasan, Alaa’ Lufti Melhem, Ewan R Pearson, Roberto Pola, Colin N A Palmer, Moneeza K Siddiqui, A gene risk score using missense variants in SLCO1B1 is associated with earlier onset statin intolerance, European Heart Journal - Cardiovascular Pharmacotherapy, Volume 9, Issue 6, September 2023, Pages 536–545, https://doi.org/10.1093/ehjcvp/pvad040 

Moneeza K Siddiqui, Cyrielle Maroteau, Abirami Veluchamy, Aleksi Tornio, Roger Tavendale, Fiona Carr, Ngu-Uma Abelega, Dan Carr, Katyrzyna Bloch, Par Hallberg, Qun-Ying Yue, Ewan R Pearson, Helen M Colhoun, Andrew D Morris, Eleanor Dow, Jacob George, Munir Pirmohamed, Paul M Ridker, Alex S F Doney, Ana Alfirevic, Mia Wadelius, Anke-Hilse Maitland-van der Zee, Daniel I Chasman, Colin N A Palmer, PREDICTION-ADR Consortium, A common missense variant of LILRB5 is associated with statin intolerance and myalgia, European Heart Journal, Volume 38, Issue 48, 21 December 2017, Pages 3569–3575, https://doi.org/10.1093/eurheartj/ehx467 

Moneeza K. Siddiqui, Christopher Hall, Scott G. Cunningham, Rory McCrimmon, Andrew Morris, Graham P. Leese, Ewan R. Pearson; Using Data to Improve the Management of Diabetes: The Tayside Experience. Diabetes Care 1 December 2022; 45 (12): 2828–2837. https://doi.org/10.2337/dci22-0003 

Supervision

Binur Orazumbekova, Wellcome Trust, Ethnic variations in risk trajectories for type 2 diabetes: an observational research study combining genetic, cohort, and electronic health record data in the UK.