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Professor Magdi Yaqoob

Joint Head of Department

Centre: Translational Medicine and Therapeutics

Email: m.m.yaqoob@qmul.ac.uk
Telephone: +44(0) 20 7882 2121

Profile

Magdi Yaqoob is Professor of Nephrology within Centre for Translational Medicine & Therapeutics at the William Harvey Research Institute (WHRI) and academic director of department of Renal Medicine and Transplantation at the Barts Health NHS Trust, UK. He graduated as one of the best graduates in Medicine (1982) from Dow Medical College, Karachi University, Pakistan. After general professional clinical training during which he obtained membership of the Royal College of Physician London (1985) he started specialist nephrology training in Liverpool, UK in 1987. He submitted his MD thesis on occupational factors in kidney disease in Liverpool University 1993. He obtained NIH fellowship to work as postdoctoral clinician/scientist under Prof Robert Schrier at Denver Colorado (194-1995).  He joined the Royal London Hospital as consultant in 1996 and was awarded personal chair in Nephrology by QMUL in 2011. He received several awards (best European young investigator of the year 1992 and trainee investigator of the year by association of physicians USA, 1994). 

Magdi Yaqoob is an internationally recognised expert in nephrology and transplant medicine in area of cardiovascular diseases of uraemia, renal anaemia, and renal bone disease, progression of chronic kidney disease and mediators of acute kidney injury.

Research

Nephrology and Transplant Medicine Research Group

We have a long-standing research interest in the pathophysiology and novel therapeutic strategies (preclinical and clinical) of:

  1. Ischaemia-reperfusion of the heart in uraemia and kidney (acute kidney injury, chronic kidney disease, renal fibrosis)
  2. Genetic factors determining the long-term outcomes of renal transplants
  3. Insulin resistance in CKD
  4. Autophagy and premature ageing in uraemia
  5. Molecular mechanisms of EPO resistance.

Over the years, we have identified a number of new therapeutic targets poly (ADP-ribose) polymerase (PARP), Hypoxiainducible factor stabilizers, calpain/caspases, acidosis, anti-inflammatory suppression of cytokine signalling, pleiotropic effects of erythropoietin their analogues, ischaemic preconditioning, sodium sensing in endothelial cells and galectins 1 & 3 in microcirculatory unit to name but a few. More recently as part of the NIHR-funded Barts-BRU, we have focused on the development of highly translational repositioning strategies, the efficacy of which is currently evaluated in patients with chronic kidney disease and transplant waiting list patient.

Publications

  • Pattar BSB, Sevinc E, Scory TD et al. (publicationYear). Risk of Hospital Readmission among People with Chronic Kidney Disease: A Population-Based Cohort Study. nameOfConference


    QMRO: qmroHref
  • Patel NSA, Kerr-Peterson HL, Brines M et al. (publicationYear). Retraction Note: Delayed administration of pyroglutamate helix B surface peptide (pHBSP), a novel nonerythropoietic analog of erythropoietin, attenuates acute kidney injury. nameOfConference


    QMRO: qmroHref
  • Young M, Aastrup M, Patel N et al. (publicationYear). Altered systemic bioenergetic reserve in chronic kidney disease predisposes hearts to worse functional outcomes. nameOfConference


  • Mohammad GH, Kieswich J, Kumar A et al. (publicationYear). Artesunate alleviates kidney fibrosis by restoring klotho protein and suppressing Wnt/β-catenin signalling pathway. nameOfConference


  • Thomas EC, Randall DW, Khurram MA et al. (publicationYear). Ethnic differences in early blood tacrolimus concentrations after kidney transplantation: a retrospective observational study. nameOfConference


  • Carswell C, Forbes T, Wilson A et al. (publicationYear). A qualitative exploration of cAregiver experienCes Of conseRvatively maNaged kidney failure: the ACORN study. nameOfConference


  • Taurbekova B, Sarsenov R, Yaqoob MM et al. (publicationYear). Cluster Analysis in Diabetes Research: A Systematic Review Enhanced by a Cross-Sectional Study. nameOfConference


  • Yu TT, Mukuba D, Casabar M et al. (2025). Management of hyperglycaemia in people with Type 1 diabetes on dialysis: What are the options? A case report and review of the literature. nameOfConference


  • Chakraborty R, Sheaff M, Yaqoob MM (2025). Donor-derived membranous nephropathy. nameOfConference


  • Chapagain A, Sharma K, Sharma S et al. (2025). WCN25-1596 INCREASED PREVALENCE OF CHRONIC KIDNEY DISEASE IN PATIENTS WITH ACTIVE TUBERCULOSIS. nameOfConference


View profile publication page

Sponsors

Collaborators

Internal

  • Prof Chris Thiemermann (WHRI)
  • Prof Mauro Perretti (WHRI)
  • Prof Amrita Ahluwalia (WHRI)
  • Prof Chris Thiemermann (WHRI)
  • Prof Roger Corder (WHRI)
  • Prof Tim Warner (WHRI)

External

  • Prof Anthony Cerami (University of Leiden, The Netherlands)
  • Dr Massimo Collino (University of Turin, Italy)
  • Prof Jonathan Sekl (Edinburgh University)
  • Prof Derek Gilroy (UCH)
  • Dr Andrew Wragg (Barthealth NHS UK)
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