Projects

Title: Mitochondrial redox metabolism as a therapeutic target in B cell lymphoma

Title: Understanding and exploiting sterol metabolism in chronic kidney disease and cancer

Title: Understanding and targeting methionine metabolism in lymphoma

Title: Preclinical models of epigenetic modulation to enhance responses to chemoradiation in locally advanced Pancreatic Cancer

Title: Exploiting fly genetics to prevent clinically-significant prostate cancer

Title: Targeting tumour infiltrating B cells to improve treatment outcomes in ovarian cancer

Title: East London genetic diversity and cell-type-specific DNA methylation

Title: Mechanistic Diversity in Maladaptive Decision-Making Among Parkinson’s Patients in East London

Title: Investigating how epigenetic dysregulation modifies cell fate in oral cancer

Title: Improving the understanding, recognition, and outcomes of linear growth faltering in pre-school children

Title: Using Host-Pathogen Interaction Dynamics to Identify Novel Drug Targets in Clinically Relevant Mycobacterium tuberculosis Isolates

Title: Investigating Rare Genetic Drivers of Fatty Liver Disease in British South Asians

Title: Simultaneous treatment of infection and fracture healing with a phage cocktail and mesenchymal stem cell composite hydrogel in fracture-related infections

Title: Long non-coding RNA regulator of Telomere length in short telomere syndrome dyskeratosis congenita

Title: iPSCs to hepatocytes: modelling cholestatic liver disease in East London

Title: Exploring Cellular Dysfunction and Therapeutic Targets in Diabetic Wound Healing: Tackiling a Hidden Disease Burden in East London

Title: Investigating the roles of endogenous retroviruses in the human placenta

Title: Dissecting the mechanism of action of thalidomide analogs in patients with Sickle cell disease and beta-thalassaemia

Title: Exploring how host-fungal dynamics in the human gut drive severe forms of inflammatory bowel disease (IBD) in South Asian patients

Title: Haematopoietic Remodelling after Major Trauma

Title: Deciphering the effect of histone acetylation levels on altered placental cell phenotype

Title: Using Non-invasive Sampling Of Tape-Strip Biopsies To Improve Eczema Therapy in the Bangladeshi population in the East-End of London

Title: Mechanisms of HHV-8 (KSHV) pathogenesis in post-renal transplant Kaposi sarcoma: Viral and host factors and the role of immunosuppressive regimens

Title: Insulin Resistance Rewires Hepatocyte Antiviral Pathways and Hepatitits B virus HBV Replication Mechanistic Insights Into a Major East London Health Inequality

Title: Head and Neck Cancer-Specific Mechanisms of Neural Invasion

Title: Effect of valproic acid on the gene regulatory landscape of gingival mast cells. A potential role for treatment of dental periodontitis

Title: Targeting DNA damage repair pathways in YAP/TAZ-driven squamous cell carcinoma as a novel therapeutic strategy

Title: Development of a novel on demand water fluoridation device for prevention of dental decay

Title: Understanding the links between gum disease and brain health: Why is periodontitis a risk factor for dementia

Title: AI for Early Diabetes Detection using Oral and Metabolic Signals

Title: Targeting XDH mutations to deliver precision medicine therapeutics for hypertension addressing a major unmet need in East London

Title: Can dietary nitrate supplementation modulate xanthine oxidoreductase activity as a driver of metabolic syndrome complications in high fructose diets?

Title: Galectin-3 as a link between joint disease and lung dysfunction in inflammatory arthritis

Title: Enriched Marine Oil Supplement as a Novel Therapeutic Approach for the Management of Inflamatory Arthritis-Associated Cardiomyopathy

Title: Senescent endothelial cells promote the accumulation of pathogenic perivascular mast cells in ageing tissues

Title: Extracellular Vesicles in Atherosclerosis: Decoding Communication and Repair

Title: CCR7-dependent neutrophil trafficking as a driver of maladaptive T-cell activation in sterile injury and rheumatoid arthritis

Title: Mitochondria as a Conduit for Precision Medicine in Inflammatory Induced Cardiomyopathy

Title: Investigating the immunomodulatory signature of TAGLN+ fibrosis-associated endothelial cells in progressive fibrotic liver disease

Title: Patient-Derived Endothelial Cells to Reveal Ethnic Differences in Coronary Artery Disease

Title: Does zinc-dependent regulation of sEH contribute to sex differences in diabetes and heart failure?

Title: From East London to Global Practice: A Multi-Modal AI Tool for Early Detection of Coronary Artery Disease

Title: Genetic basis of autoimmune disease in British South Asians

Title: Addressing Health Inequalities in Access to Device-Assisted Therapies for Parkinson’s Disease in East London

Title: Investigating the links between cardiometabolic risk factors and dementia in South Asians

Title: Delays in type 2 diabetes diagnosis & management in Black and mixed ethnicity people: a population data-driven study to improve NHS care and outcomes

Title: Future risk of cancer after urgent suspected cancer referral